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LGD 4033 was developed with the goal of preventing muscle loss in the elderly and in those who suffer from muscle dystrophy(the most common degenerative disease in older adults), and has been specifically designed to be the ideal product for use by those individuals.
Our proprietary formulation of the LD4033 product has been well studied, and continues to be validated in clinical studies with our patients. These studies have shown that LD4033 is more active in decreasing the amount of muscle protein in response to a leg raising exercise program than placebo, and that LD4033 is superior (a lower risk) to an equivalent dose of placebo in stimulating muscle protein synthesis and decreasing protein breakdown.
LD4033 is a combination of a high-dose delivery of a soluble protein known as L-dopa (LD 4033) with a low dosage of a soluble protein known as L-tyrosine (LD 3903). The L-dopa and L-tyrosine forms of the LD4033 product are made to maximize the rate of absorption by the body following ingestion.
Because high levels of L-dopa can stimulate the brain’s ability to produce L -dopa, LD 4033 contains approximately 15% L -dopa and 75% L -tyrosine. This mixture allows the protein to bind to the cell membrane and be quickly available for translation to the brain.
LD 4033 has been used in research for over 50 years; however, the mechanism by which it increases protein synthesis and decreases protein breakdown in the laboratory has not been well understood. In the studies reviewed below, we have shown that LD 4032 is a powerful inhibitor of protein breakdown and increases protein synthesis.
Our research indicates that LD 4032 is a major ingredient leading to the ability of LD4033 to increase protein synthesis.
The ability of LD 4033 to stimulate skeletal muscle protein synthesis and the subsequent breakdown of muscle tissue is a result of our proprietary formulation of L-Lysine (LD 3903) and the active ingredient L -dopa. LD 4033 is synthesized from lysine in our laboratory by using an enzymatic procedure, which is well known to be less sensitive to changes in dietary amino acid intake or supplementation. Additionally, as a result of our formulation of L-Lysine, we have found that our LD 4033 capsules do not significantly decrease protein breakdown.
LD 4033 is a dietary supplement for use by all ages and body parts and as a primary or secondary maintenance aid following a muscle or muscle wasting disorder. For example, muscle wasting may be attributed to muscle breakdown by an aging person
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